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KMID : 0882420020630030322
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Korean Journal of Medicine
2002 Volume.63 No. 3 p.322 ~ p.328
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Bone metastasis of gastric cancer -Clinical evaluation on bone scintigram-
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Kim Young-Hwan
Chae Hiun-Suk
Cho Young-Seok
Lee Bo-In
Kim Byung-Wook
Kim Sung-Soo
Han Sok-Won
Lee Chang-Don
Choi Gyu-Yong
Cha Sang-Bog
Chung In-Sik
Sun Hee-Sik
Chun Kyung-Ah
Lim Keun-Woo
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Abstract
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Background: It has been known that bone metastasis rarly occurs in gastric cancer, compared with lung and breast cancers. But its incidence is variable according to authors and has not been reported in Korea. We investigated the incidence and related clinical parameters of bone metastasis.
Methods: We studied a total of 226 gastric cancer patients who were diagnosed by endoscopic biopsy at Our Lady of Mercy Hospital and UijongBu St. Mary’s Hospital from 1993 to 2000. We performed abdominal CT and bone scan at teh time of cancer diagnosis in all patients. The data of parameters including gross findings on gastrofibroscopy, histology, laboratory findings were obtained for analysis.
Results: 226 patietns (male : 158 patients, female :68 patients) were included and their mean age was 58.9±13.0 years. The rate of early gastric cancer was 24.8% and 75.2% for advanced cancer. Theincidence of bone metastasis based on bone scintigram was 11.9% (27/226 subjects) and the main involvement sites wer spine (81.5%), rib (74.1%), skull (29.6%), pelvis (14.8%). The incidence was higher in advanced stage or corpus location or elevated CEA level. Other parameters including age, sex, pathology, endoscopic gross morphology, levels of Ca, alkaline phosphatase were not significant in relation to bone metastasis. Bone metastasis was more related to lung metastasis than liver metastsis.
Conclusions: In our study, bone metastasis is not rare in gastric cancer. Therefore, the evaluation of it should be performed selectively according to the staging, tumor location and tumor marker level.
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KEYWORD
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Stomach neoplasm, Bone scintigraphy, Metastasis
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